A French woman who received the world’s first partial face transplant in 2005 has died aged 49.
Isabelle Dinoire underwent the revolutionary surgery after her nose,
mouth and chin were mauled by her pet Labrador. Her injuries meant she
had difficulty speaking and eating.
Doctors at Amiens Hospital in Valenciennes, northern France, grafted
the face of a brain-dead female donor on to Ms Dinoire’s during the
procedure, which has since been replicated dozens of times across the
world.
Ms Dinoire succumbed to two forms of cancer on 22 April, a statement released by the hospital on Tuesday said.
The hospital said they did not announce her death at the time due to a
request for privacy from her family during “this painful time”.
Ms Dinoire had to take powerful immunosuppressive drugs following the
surgery in November 2005 to stop her body rejecting the face but the
side effects of the drugs include a weaker immune system.
Despite this her surgeon, Professor Bernard Devauchelle, was still positive about the results during a public lecture in 2011.
He said she was doing “very well” and “the results went beyond what we had hoped...This first attempt was a masterstroke”.

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